CDMO Technology Domain
Analytical Methods & PAT — Page 2
Process Analytical Technology (PAT) and advanced characterisation: Raman spectroscopy, NIR, HPLC, ICP-MS for heavy metals, and botanical adulterant profiling.
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dossiers
Cellular Longevity & Senolytics
Cellular Senescence, SASP, and Senolytic Targeting of Age-Related Pathologies
Delivering senolytics effectively to specific senescent cell populations and overcoming their multi-pathway pro-survival redundancy (SCAPs) without off-target effects remains a significant challenge for therapeutic development.
Intracellular Defense & IV-Alternatives
De Novo Generative AI Drug Design: Clinical Progress and Methodological Landscape
Developing novel therapeutic molecules with high specificity and optimized pharmacological profiles rapidly, particularly for challenging targets, requires innovative and efficient design methodologies beyond traditional discovery pipelines.
Intracellular Defense & IV-Alternatives
Oxidative Stress Mitigation in Nutraceutical Stability: Packaging and Formulation Strategies
Nutraceutical dosage forms face significant degradation due to oxidative stress, driven by moisture, oxygen, and light. This presents a challenge for maintaining stability across supply-chain conditions and long shelf lives.
Intracellular Defense & IV-Alternatives
Non-Destructive Raman Spectroscopy for PAT-Based Botanical Contaminant Detection
Ensuring real-time quality control of botanical APIs is hindered by the need to detect trace contaminants, such as pesticide residues or adulterants, in heterogeneous botanical matrices while meeting regulatory sensitivity requirements.
Cellular Longevity & Senolytics
Synergistic Modulation of Cellular Senescence Biomarkers by Target-Specific Nutraceutical Matrices
Developing a nutraceutical matrix that precisely modulates senescence-related biomarkers requires integrating senolytic activity, SASP suppression, and mitochondrial restoration within a single formulation while ensuring in vitro reproducibility and scalability.
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